Detalhe da pesquisa
1.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894487
2.
Preparation, biological & cheminformatics-based assessment of N2,N4-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials.
Bioorg Med Chem
; 46: 116348, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34479064
3.
Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators.
Bioorg Chem
; 115: 105215, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34358799
4.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
5.
Screening a protein kinase inhibitor library against Plasmodium falciparum.
Malar J
; 16(1): 446, 2017 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29115999
6.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
7.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature
; 464(7289): 728-32, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360736
8.
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.
Antimicrob Agents Chemother
; 57(7): 2913-22, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23571538
9.
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
J Med Chem
; 66(13): 8896-8916, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37343180
10.
Quinol derivatives as potential trypanocidal agents.
Bioorg Med Chem
; 20(4): 1607-15, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264753
11.
Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials.
RSC Med Chem
; 13(12): 1587-1604, 2022 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36561069
12.
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
ACS Infect Dis
; 8(9): 1962-1974, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037410
13.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
ChemMedChem
; 17(22): e202200393, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129427
14.
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials.
J Med Chem
; 64(22): 16450-16463, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34748707
15.
Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives.
ACS Med Chem Lett
; 11(12): 2497-2503, 2020 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335673
16.
Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials.
J Med Chem
; 63(20): 11585-11601, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32678591
17.
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.
ACS Infect Dis
; 5(1): 111-122, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30380837
18.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540
19.
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
J Med Chem
; 61(18): 8374-8389, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30207721
20.
The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug.
FEBS Lett
; 581(24): 4749-53, 2007 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17870073